Review of Infectious Borrelia species Chronic Brain Infections and the Development of Alzheimer’s Disease from Alan MacDonald on Vimeo.

This is a 37 minute video describing important research into Borrelia Chronic Brain Infections and the development of Alzheimer’s disease by Alan B. MacDonald,MD.

Included in this lecture are select citations from the work of Dr. Judith Miklossy, MD,PhD,ScD, also connecting Chronic Spirochaetal Brain Infections, Borrelia species, and Oral Treponema Species of Spirochaetes with the development of future Alzheimer’s disease.

The research tools used by Dr. Alan MacDonald includes: Culture of Fresh Autopsy Alzheimer’s Brain tissue with Positive recovery of Borrelia burgdorferi spirochaetes in Vitro ( 5 cases).

The use of Borrelia burgdorferi Specific DNA probes to image single Borrelia spirochaetes, and to image Biofilm Communities of Borrelia Spirochaetes in Alzheimer’s Amyloid Plaques. Single Cortical Brain neurons with Granulovacuolar Degeneration ( GVB), and single Borrelia spirochaetes in brain tissue between the Plaques and the GVB lesions.

Notably, Dr. MacDonald, calls to attention the role of Granular Borrelia as viable and virulent pathogens distinct from the Spiral Borrelia corkscrew shaped forms.

The role of Round body Borrelia (cystic borrelia) in the evolution of Alzheimer’s disease, and the
paramount role to biofilm communities of Borrelia in granular form as the actual nidus of the Amyloid Plaques seen in Alzheimer’s disease autopsy brain tissues.


It was in 1986, that Dr Alan MacDonald first found and cultured Borrelia spirochaetes from Alzheimer’s brains. His findings were published in the Journal of the American Medical Association:

Links to further information regarding Dr MacDonald’s work can be found on his website –