Potential Persistent Borrelia Infection and Response to Antibiotic Therapy; a Clinical Case Study and Review of Recent Literature
Peer Reviewed Evidence of Persistence of Lyme Disease Spirochete Borrelia burgdorferi and Tick-Borne Diseases
A list of over 700 peer reviewed articles that support the evidence of persistence of Lyme and other tick-borne diseases. It is organized into different categories—general, psychiatric, dementia, autism and congenital transmission. Link here
Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease.
Middelveen MJ, Sapi E, Burke J, Filush KR, Franco A, Fesler MC, Stricker RB
Plasticity in early immune evasion strategies of a bacterial pathogen
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Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding
Monica E. Embers , Nicole R. Hasenkampf, Mary B. Jacobs, Amanda C. Tardo, Lara A. Doyle-Meyers, Mario T. Philipp, Emir Hodzic
Resurgence of persisting non-cultivable Borrelia burgdorferi following antibiotic treatment in mice.
Hodzic E, Imai D, Feng S, Barthold SW
Late Disseminated Lyme Disease Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques
Sleeper cells: the stringent response and persistence in the Borreliella (Borrelia) burgdorferi enzootic cycle.
Cabello FC, Godfrey HP, Bugrysheva JV, Newman SA
Chronic Lyme Disease: A Working Case Definition
Review of evidence for immune evasion and persistent infection in Lyme disease
Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-like Microcolony B. burgdorferi Persisters Which Are Sterilized by Daptomycin/Doxycycline/Cefuroxime Drug Combination without Pulse Dosing
An Immune Evasion Mechanism for Spirochetal Persistence in Lyme Borreliosis
Fang Ting Liang, Mary B. Jacobs, , and Mario T. Philipp
Transformation of cystic forms of Borrelia burgdorferi to normal, mobile spirochetes.
Brorson O,Brorson SH.
Borrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cells.
Bijaya Sharma,Autumn V. Brown,Nicole E. Matluck,Linden T. Hu andKim Lewis
Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library
Jie Feng, Ting Wang, Wanliang Shi, Shuo Zhang, David Sullivan, Paul G Auwaerter and Ying Zhang
Table 1. Activity of top 27 active hits with better activity than the current Lyme disease antibiotics against stationary-phase B. burgdorferi persisters
Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection
Drug Combinations against Borrelia burgdorferi Persisters In Vitro: Eradication Achieved by Using Daptomycin, Cefoperazone and Doxycycline
Jie Feng, Paul G. Auwaerter, Ying Zhang
An Optimized SYBR Green I/PI Assay for Rapid Viability Assessment and Antibiotic Susceptibility Testing for Borrelia burgdorferi
Persister mechanisms in Borrelia burgdorferi: implications for improved intervention