Borrelia Persistence

 

Sleeper cells: the stringent response and persistence in the Borreliella (Borrelia) burgdorferi enzootic cycle.  

Cabello FC, Godfrey HP, Bugrysheva JV, Newman SA

 

Chronic Lyme Disease: A Working Case Definition

Stricker RB* and Fesler MC

 

LIST OF 700 ARTICLES CITING CHRONIC INFECTION ASSOCIATED WITH TICK-BORNE DISEASE COMPILED BY DR. ROBERT BRANSFIELD  http://www.ilads.org/ilads_news/2015/list-of-700-articles-citing-chronic-infection-associated-with-tick-borne-disease-compiled-by-dr-robert-bransfield/ 

 also PDF here  http://www.ilads.org/ilads_news/wp-content/uploads/2015/09/EvidenceofPersistence-V2.pdf

 

Review of evidence for immune evasion and persistent infection in Lyme disease

Keith Berndtson

 

Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-like Microcolony B. burgdorferi Persisters Which Are Sterilized by Daptomycin/Doxycycline/Cefuroxime Drug Combination without Pulse Dosing

Jie Feng, Shuo Zhang, Wanliang Shi and Ying Zhang

  

An Immune Evasion Mechanism for Spirochetal Persistence in Lyme Borreliosis 

Fang Ting Liang, Mary B. Jacobs, , and Mario T. Philipp

 

 Transformation of cystic forms of Borrelia burgdorferi to normal, mobile spirochetes.

Brorson O,Brorson SH.

Infection.1997 Jul-Aug;25(4):240-6.

 

Borrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cells.

Bijaya Sharma,Autumn V. Brown,Nicole E. Matluck,Linden T. Hu andKim Lewis

 

Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library

Jie Feng, Ting Wang, Wanliang Shi, Shuo Zhang, David Sullivan, Paul G Auwaerter and Ying Zhang

Table 1. Activity of top 27 active hits with better activity than the current Lyme disease antibiotics against stationary-phase B. burgdorferi persisters 

 

Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection

Jie Feng, Wanliang Shi, Shuo Zhang and Ying Zhang

 

Persister mechanisms in Borrelia burgdorferi: implications for improved intervention

Jie Feng, Wanliang Shi, Shuo Zhang and Ying Zhang

 

 Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime

Jie Feng, Megan Weitner, Wanliang Shi, Shuo Zhang and Ying Zhang*
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA

 

Are Mycobacterium Drugs Effective for Treatment Resistant Lyme Disease, TickBorne Co-Infections, and Autoimmune Disease?

Richard I. Horowitz* and Phyllis R. Freeman

 

Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

Craft JE, Fischer DK, Shimamoto GT, Steere AC.
‘The appearance of a new IgM response and the expansion of the IgG response late in the illness, and the lack of such responses in patients with early disease alone, suggest that B. burgdorferi remains alive throughout the illness.’